ace inhibitors in heart failure

What is the proposed mechanism of action for beta blockers in the treatment of heart failure?_15.jpg

What is the proposed mechanism of action for beta blockers in the treatment of heart failure?

Increased adrenergic activity in patients with congestive heart failure can downregulate cardiac beta-adrenergic receptors and cause peripheral vasoconstriction. Beta blockers can attenuate these deleterious effects of chronic catecholamine stimulation. Clinically, this has translated into improvements in hemodynamics, symptoms, exercise tolerance, and left ventricular function. Beta blockers, however, have not been shown to decrease mortality in […] Read more