In general, stopping smoking resulted in a 50-70% reduction in CAD risk at the end of 5 years. When combined with lowering of dietary cholesterol in the Oslo study, the incidence of myocardial infarction (fatal and nonfatal) and the CAD death rate were 47% and 55% lower than
Coronary Risk Factors and Modification those in the control group. Similar results were observed in the Multiple Risk Factor Intervention Trial (MRFIT), in which hypertensive treatment was combined with smoking cesation.
With control of hypertension, is there a reduction in myocardial infarction?
Meta-analysis of 14 randomized trials showed that a reduction of 5-6 mmHg in diastolic pressure was associated with a 42% reduction in stroke incidence but only a 14% decrement in myocardial infarction incidence. The reason for this difference remains to be defined.
The target goal in reducing the elevated blood pressure also remained unestablished. The second US Joint National Committee provided an initial goal to maintain the diastolic pressure under 90 mm Hg. Recent studies have found that a myocardial infarction risk reduction was achieved if the diastolic pressure was reduced to 84 mmHg.